1D4R

29-mer fragment of human srp rna helix 6

1D4R の概要

• エントリーDOI: 10.2210/pdb1d4r/pdb
• 分子名称: 29-MER OF MODIFIED SRP RNA HELIX 6, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: a-rna helix, ggag/gagg bulge, ac/ca tandem mismatch, gu wobble base pairs, 2'3' -cyclic phosphate, rna
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 28649.46

構造登録者

Wild, K.,Weichenrieder, O.,Leonard, G.A.,Cusack, S. (登録日: 1999-10-05, 公開日: 1999-12-02, 最終更新日: 2024-02-07)

主引用文献

Wild, K.,Weichenrieder, O.,Leonard, G.A.,Cusack, S.
The 2 A structure of helix 6 of the human signal recognition particle RNA
Structure Fold.Des., 7:1345-1352, 1999

PubMed Abstract: The mammalian signal recognition particle (SRP) is an essential cytoplasmic ribonucleoprotein complex involved in targeting signal-peptide-containing proteins to the endoplasmic reticulum. Assembly of the SRP requires protein SRP19 to bind first to helix 6 of the SRP RNA before the signal-peptide-recognizing protein, SRP54, can bind to helix 8 of the RNA. Helix 6 is closed by a GGAG tetraloop, which has been shown to form part of the SRP19-binding site.

PubMed: 10574798
DOI: 10.1016/S0969-2126(00)80024-6

実験手法

X-RAY DIFFRACTION (2 Å)