1D4M

THE CRYSTAL STRUCTURE OF COXSACKIEVIRUS A9 TO 2.9 A RESOLUTION

1D4M の概要

• エントリーDOI: 10.2210/pdb1d4m/pdb
• 分子名称: PROTEIN (COXSACKIEVIRUS A9), 5-(7-(4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, MYRISTIC ACID, ... (7 entities in total)
• 機能のキーワード: picornavirus structure, rgd, uncoating, virus-receptor interaction, win compound, virus/viral protein, icosahedral virus, virus
• 由来する生物種: Human coxsackievirus A9; 詳細
• 細胞内の位置: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P21404 P21404 P21404 P21404
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 97354.88

構造登録者

Hendry, E.,Hatanaka, H.,Fry, E.,Smyth, M.,Tate, J.,Stanway, G.,Santti, J.,Maaronen, M.,Hyypia, T.,Stuart, D. (登録日: 1999-10-04, 公開日: 1999-12-23, 最終更新日: 2024-10-30)

主引用文献

Hendry, E.,Hatanaka, H.,Fry, E.,Smyth, M.,Tate, J.,Stanway, G.,Santti, J.,Maaronen, M.,Hyypia, T.,Stuart, D.
The crystal structure of coxsackievirus A9: new insights into the uncoating mechanisms of enteroviruses.
Structure Fold.Des., 7:1527-1538, 1999

PubMed Abstract: Coxsackievirus A9 (CAV9), a human pathogen causing symptoms ranging from common colds to fatal infections of the central nervous system, is an icosahedral single-stranded RNA virus that belongs to the genus Enterovirus of the family Picornaviridae. One of the four capsid proteins, VP1, includes the arginine-glycine-aspartate (RGD) motif within its C-terminal extension. This region binds to integrin alpha v beta 3, the only receptor for CAV9 to be conclusively identified to date.

PubMed: 10647183
DOI: 10.1016/S0969-2126(00)88343-4

実験手法

X-RAY DIFFRACTION (2.9 Å)