1D38

INFLUENCE OF AGLYCONE MODIFICATIONS ON THE BINDING OF ANTHRACYCLINE DRUGS TO DNA: THE MOLECULAR STRUCTURE OF IDARUBICIN AND 4-O-DEMETHYL-11-DEOXYDOXORUBICIN COMPLEXED TO D(CGATCG)

Summary for 1D38

• Entry DOI: 10.2210/pdb1d38/pdb
• Descriptor: DNA (5'-D(*CP*GP*AP*TP*CP*G)-3'), IDARUBICIN, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: right handed dna, double helix, complexed with drug, dna
• Total number of polymer chains: 1
• Total formula weight: 2331.02

Authors

Gao, Y.-G.,Wang, A.H.-J. (deposition date: 1991-04-23, release date: 1992-04-15, Last modification date: 2024-02-07)

• Primary citation: Gao, Y.G.,Wang, A.H.; Influence of aglycone modifications on the binding of anthracycline drugs to DNA: the molecular structure of idarubicin and 4-O-demethyl-11-deoxydoxorubicin complexed to d(CGATCG).; Anti-Cancer Drug Des., 6:137-149, 1991; PubMed: 1872945

Experimental method

X-RAY DIFFRACTION (1.7 Å)