1D2P

CRYSTAL STRUCTURE OF TWO B REPEAT UNITS (B1B2) OF THE COLLAGEN BINDING PROTEIN (CNA) OF STAPHYLOCOCCUS AUREUS

Summary for 1D2P

• Entry DOI: 10.2210/pdb1d2p/pdb
• Related: 1AMX 1D2O
• Descriptor: COLLAGEN ADHESIN (2 entities in total)
• Functional Keywords: collagen, igg, igsf, mscramm, cna, staphylococcus aureus, structural protein
• Biological source: Staphylococcus aureus
• Cellular location: Secreted, cell wall; Peptidoglycan-anchor (Potential): Q53654
• Total number of polymer chains: 1
• Total formula weight: 42413.16

Authors

Deivanayagam, C.C.S.,Rich, R.L.,Hook, M.,Narayana, S.V.L. (deposition date: 1999-09-25, release date: 2000-09-27, Last modification date: 2024-02-07)

Primary citation

Deivanayagam, C.C.,Rich, R.L.,Carson, M.,Owens, R.T.,Danthuluri, S.,Bice, T.,Hook, M.,Narayana, S.V.
Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein.
Structure Fold.Des., 8:67-78, 2000

PubMed Abstract: [corrected] The Staphylococcus aureus collagen-binding protein Cna mediates bacterial adherence to collagen. The primary sequence of Cna has a non-repetitive collagen-binding A region, followed by the repetitive B region. The B region has one to four 23 kDa repeat units (B(1)-B(4)), depending on the strain of origin. The affinity of the A region for collagen is independent of the B region. However, the B repeat units have been suggested to serve as a 'stalk' that projects the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. To understand the biological role of these B-region repeats we determined their three-dimensional structure.

PubMed: 10673425
DOI: 10.1016/S0969-2126(00)00081-2

Experimental method

X-RAY DIFFRACTION (2.5 Å)