1D2O

CRYSTAL STRUCTURE OF A SINGLE B REPEAT UNIT (B1) OF COLLAGEN BINDING SURFACE PROTEIN (CNA) OF STAPHYLOCOCCUS AUREUS.

1D2O の概要

• エントリーDOI: 10.2210/pdb1d2o/pdb
• 関連するPDBエントリー: 1AMX 1D2P
• 分子名称: COLLAGEN ADHESIN (2 entities in total)
• 機能のキーワード: beta sandwich, igg, igsf, cna, staphylococcus aureus, collagen, structural protein
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42528.39

構造登録者

Deivanayagam, C.C.S.,Rich, R.L.,Hook, M.,Narayana, S.V.L. (登録日: 1999-09-25, 公開日: 2000-09-27, 最終更新日: 2024-02-07)

主引用文献

Deivanayagam, C.C.,Rich, R.L.,Carson, M.,Owens, R.T.,Danthuluri, S.,Bice, T.,Hook, M.,Narayana, S.V.
Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein.
Structure Fold.Des., 8:67-78, 2000

PubMed Abstract: [corrected] The Staphylococcus aureus collagen-binding protein Cna mediates bacterial adherence to collagen. The primary sequence of Cna has a non-repetitive collagen-binding A region, followed by the repetitive B region. The B region has one to four 23 kDa repeat units (B(1)-B(4)), depending on the strain of origin. The affinity of the A region for collagen is independent of the B region. However, the B repeat units have been suggested to serve as a 'stalk' that projects the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. To understand the biological role of these B-region repeats we determined their three-dimensional structure.

PubMed: 10673425
DOI: 10.1016/S0969-2126(00)00081-2

実験手法

X-RAY DIFFRACTION (2 Å)