1CWV

CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN

1CWV の概要

• エントリーDOI: 10.2210/pdb1cwv/pdb
• 分子名称: INVASIN, CITRIC ACID (3 entities in total)
• 機能のキーワード: integrin-binding protein, inv gene, structural protein
• 由来する生物種: Yersinia pseudotuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52131.54

構造登録者

Bjorkman, P.J.,Hamburger, Z.A. (登録日: 1999-08-26, 公開日: 1999-10-13, 最終更新日: 2011-07-13)

主引用文献

Hamburger, Z.A.,Brown, M.S.,Isberg, R.R.,Bjorkman, P.J.
Crystal structure of invasin: a bacterial integrin-binding protein.
Science, 286:291-295, 1999

PubMed Abstract: The Yersinia pseudotuberculosis invasin protein promotes bacterial entry by binding to host cell integrins with higher affinity than natural substrates such as fibronectin. The 2.3 angstrom crystal structure of the invasin extracellular region reveals five domains that form a 180 angstrom rod with structural similarities to tandem fibronectin type III domains. The integrin-binding surfaces of invasin and fibronectin include similarly located key residues, but in the context of different folds and surface shapes. The structures of invasin and fibronectin provide an example of convergent evolution, in which invasin presents an optimized surface for integrin binding, in comparison with host substrates.

PubMed: 10514372
DOI: 10.1126/science.286.5438.291

実験手法

X-RAY DIFFRACTION (2.3 Å)