1CTR

DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX

1CTR の概要

• エントリーDOI: 10.2210/pdb1ctr/pdb
• 分子名称: CALMODULIN, CALCIUM ION, 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE (3 entities in total)
• 機能のキーワード: calcium-binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, spindle: P62158
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17289.16

構造登録者

Cook, W.J.,Walter, L.J.,Walter, M.R. (登録日: 1994-09-21, 公開日: 1994-12-20, 最終更新日: 2024-02-07)

主引用文献

Cook, W.J.,Walter, L.J.,Walter, M.R.
Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex.
Biochemistry, 33:15259-15265, 1994

PubMed Abstract: The crystal structure of calmodulin (CaM) bound to trifluoperazine (TFP) has been determined and refined to a resolution of 2.45 A. Only one TFP is bound to CaM, but that is sufficient to cause distortion of the central alpha-helix and juxtaposition of the N- and C-terminal domains similar to that seen in CaM-polypeptide complexes. The drug makes extensive contacts with residues in the C-terminal domain of CaM but only a few contacts with one residue in the N-terminal domain. The structure suggests that substrate binding to the C-terminal domain is sufficient to cause the conformational changes in calmodulin that lead to activation of its targets.

PubMed: 7803388
DOI: 10.1021/bi00255a006

実験手法

X-RAY DIFFRACTION (2.45 Å)