1CSN

BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP

1CSN の概要

• エントリーDOI: 10.2210/pdb1csn/pdb
• 分子名称: CASEIN KINASE-1, MAGNESIUM ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: phosphotransferase
• 由来する生物種: Schizosaccharomyces pombe (fission yeast)
• 細胞内の位置: Cytoplasm: P40233
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35100.85

構造登録者

Xu, R.-M.,Cheng, X. (登録日: 1995-04-25, 公開日: 1995-07-31, 最終更新日: 2024-02-07)

主引用文献

Xu, R.M.,Carmel, G.,Sweet, R.M.,Kuret, J.,Cheng, X.
Crystal structure of casein kinase-1, a phosphate-directed protein kinase.
EMBO J., 14:1015-1023, 1995

PubMed Abstract: The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.

PubMed: 7889932

実験手法

X-RAY DIFFRACTION (2 Å)