1CQA

BIRCH POLLEN PROFILIN

Summary for 1CQA

Entry DOI	10.2210/pdb1cqa/pdb
Descriptor	PROFILIN (2 entities in total)
Functional Keywords	actin-binding protein, allergen, contractile protein
Biological source	Betula pendula (European white birch)
Total number of polymer chains	1
Total formula weight	14293.19
Authors	Fedorov, A.A.,Ball, T.,Mahoney, N.M.,Valenta, R.,Almo, S.C. (deposition date: 1996-07-26, release date: 1997-02-12, Last modification date: 2024-02-07)
Primary citation	Fedorov, A.A.,Ball, T.,Mahoney, N.M.,Valenta, R.,Almo, S.C. The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin. Structure, 5:33-45, 1997 Cited by PubMed Abstract: The profilins are a group of ubiquitous actin monomer binding proteins that are responsible for regulating the normal distribution of filamentous actin networks in eukaryotic cells. Profilins also bind polyphosphoinositides, which can disrupt the profilin-action complex, and proline-rich ligands which localize profilin to sites requiring extensive actin filament accumulation. Profilins represent cross-reactive allergens for almost 20 % of all pollen allergic patients. PubMed: 9016715 DOI: 10.1016/S0969-2126(97)00164-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation