1CQA

BIRCH POLLEN PROFILIN

1CQA の概要

• エントリーDOI: 10.2210/pdb1cqa/pdb
• 分子名称: PROFILIN (2 entities in total)
• 機能のキーワード: actin-binding protein, allergen, contractile protein
• 由来する生物種: Betula pendula (European white birch)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14293.19

構造登録者

Fedorov, A.A.,Ball, T.,Mahoney, N.M.,Valenta, R.,Almo, S.C. (登録日: 1996-07-26, 公開日: 1997-02-12, 最終更新日: 2024-02-07)

主引用文献

Fedorov, A.A.,Ball, T.,Mahoney, N.M.,Valenta, R.,Almo, S.C.
The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin.
Structure, 5:33-45, 1997

PubMed Abstract: The profilins are a group of ubiquitous actin monomer binding proteins that are responsible for regulating the normal distribution of filamentous actin networks in eukaryotic cells. Profilins also bind polyphosphoinositides, which can disrupt the profilin-action complex, and proline-rich ligands which localize profilin to sites requiring extensive actin filament accumulation. Profilins represent cross-reactive allergens for almost 20 % of all pollen allergic patients.

PubMed: 9016715
DOI: 10.1016/S0969-2126(97)00164-0

実験手法

X-RAY DIFFRACTION (2.4 Å)