1CQ3

STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS

1CQ3 の概要

• エントリーDOI: 10.2210/pdb1cq3/pdb
• 分子名称: VIRAL CHEMOKINE INHIBITOR (2 entities in total)
• 機能のキーワード: beta sandwich, chemokine, cytokine
• 由来する生物種: Cowpox virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50766.07

構造登録者

Carfi, A.,Smith, C.A.,Smolak, P.J.,McGrew, J.,Wiley, D.C. (登録日: 1999-08-05, 公開日: 1999-11-12, 最終更新日: 2024-10-16)

主引用文献

Carfi, A.,Smith, C.A.,Smolak, P.J.,McGrew, J.,Wiley, D.C.
Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus.
Proc.Natl.Acad.Sci.USA, 96:12379-12383, 1999

PubMed Abstract: Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses as anti-inflammatory agents. We have determined the crystal structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence factor. The molecule is a beta-sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta-sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.

PubMed: 10535930
DOI: 10.1073/pnas.96.22.12379

実験手法

X-RAY DIFFRACTION (1.85 Å)