1COK

STRUCTURE OF THE C-TERMINAL DOMAIN OF P73

1COK の概要

• エントリーDOI: 10.2210/pdb1cok/pdb
• NMR情報: BMRB: 4413
• 分子名称: PROTEIN (SECOND SPLICE VARIANT P73) (1 entity in total)
• 機能のキーワード: p73 sam-like domain, gene regulation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O15350
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7808.81

構造登録者

Chi, S.-W.,Ayed, A.,Arrowsmith, C.H. (登録日: 1999-05-28, 公開日: 1999-08-17, 最終更新日: 2023-12-27)

主引用文献

Chi, S.W.,Ayed, A.,Arrowsmith, C.H.
Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.
EMBO J., 18:4438-4445, 1999

PubMed Abstract: p73 and p63 are two recently cloned genes with homology to the tumor suppressor p53, whose protein product is a key transcriptional regulator of genes involved in cell cycle arrest and apoptosis. While all three proteins share conserved transcriptional activation, DNA-binding and oligomerization domains, p73 and p63 have an additional conserved C-terminal region. We have determined the three-dimensional solution structure of this conserved C-terminal domain of human p73. The structure reveals a small five-helix bundle with striking similarity to the SAM (sterile alpha motif) domains of two ephrin receptor tyrosine kinases. The SAM domain is a putative protein-protein interaction domain found in a variety of cytoplasmic signaling proteins and has been shown to form both homo- and hetero-oligomers. However, the SAM-like C-terminal domains of p73 and p63 are monomeric and do not interact with one another, suggesting that this domain may interact with additional, as yet uncharacterized proteins in a signaling and/or regulatory role.

PubMed: 10449409
DOI: 10.1093/emboj/18.16.4438

実験手法

SOLUTION NMR