1CKA

STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK

1CKA の概要

• エントリーDOI: 10.2210/pdb1cka/pdb
• 分子名称: C-CRK N-TERMINAL SH3 DOMAIN, C3G PEPTIDE (PRO-PRO-PRO-ALA-LEU-PRO-PRO-LYS-LYS-ARG) (3 entities in total)
• 機能のキーワード: complex (oncogene protein-peptide), complex (oncogene protein-peptide) complex, complex (oncogene protein/peptide)
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7917.92

構造登録者

Wu, X.,Kuriyan, J. (登録日: 1995-01-24, 公開日: 1995-05-08, 最終更新日: 2024-02-07)

主引用文献

Wu, X.,Knudsen, B.,Feller, S.M.,Zheng, J.,Sali, A.,Cowburn, D.,Hanafusa, H.,Kuriyan, J.
Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk.
Structure, 3:215-226, 1995

PubMed Abstract: Proline-rich segments in the guanine nucleotide exchange factor C3G bind much more strongly to the N-terminal Src homology 3 domain (SH3-N) of the proto-oncogene product c-Crk than to other SH3 domains. The presence of a lysine instead of an arginine in the peptides derived from C3G appears to be crucial for this specificity towards c-Crk.

PubMed: 7735837
DOI: 10.1016/S0969-2126(01)00151-4

実験手法

X-RAY DIFFRACTION (1.5 Å)