1CFP

S100B (S100BETA) NMR DATA WAS COLLECTED FROM A SAMPLE OF CALCIUM FREE PROTEIN AT PH 6.3 AND A TEMPERATURE OF 311 K AND 1.7-6.9 MM CONCENTRATION, 25 STRUCTURES

Summary for 1CFP

• Entry DOI: 10.2210/pdb1cfp/pdb
• Descriptor: S100B (1 entity in total)
• Functional Keywords: helix-loop-helix, calcium-binding protein
• Biological source: Bos taurus (cattle)
• Cellular location: Cytoplasm: P02638
• Total number of polymer chains: 2
• Total formula weight: 21363.95

Authors

Kilby, P.M.,Vaneldik, L.J.,Roberts, G.C.K. (deposition date: 1996-06-04, release date: 1997-03-12, Last modification date: 2024-05-22)

Primary citation

Kilby, P.M.,Van Eldik, L.J.,Roberts, G.C.
The solution structure of the bovine S100B protein dimer in the calcium-free state.
Structure, 4:1041-1052, 1996

PubMed Abstract: S100B (S100beta) is a member of the S100 family of small calcium-binding proteins: members of this family contain two helix-loop-helix calcium-binding motifs and interact with a wide range of proteins involved mainly in the cytoskeleton and cell proliferation. S100B is a neurite-extension factor and levels of S100B are elevated in the brains of patients with Alzheimer's disease or Down's syndrome: the pattern of S100B overexpression in Alzheimer's disease correlates with the pattern of neuritic-plaque formation. Identification of a growing class of S100 proteins and the likely neurochemical importance of S100B make the determination of the structure of S100B of interest.

PubMed: 8805590
DOI: 10.1016/S0969-2126(96)00111-6

Experimental method

SOLUTION NMR