1CFB

CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS

1CFB の概要

• エントリーDOI: 10.2210/pdb1cfb/pdb
• 分子名称: DROSOPHILA NEUROGLIAN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: neural adhesion molecule
• 由来する生物種: Drosophila melanogaster (fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23808.05

構造登録者

Huber, A.H.,Wang, Y.E.,Bieber, A.J.,Bjorkman, P.J. (登録日: 1994-08-27, 公開日: 1994-11-30, 最終更新日: 2024-10-30)

主引用文献

Huber, A.H.,Wang, Y.M.,Bieber, A.J.,Bjorkman, P.J.
Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A.
Neuron, 12:717-731, 1994

PubMed Abstract: We report the crystal structure of two adjacent fibronectin type III repeats from the Drosophila neural cell adhesion molecule neuroglian. Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains. The hydrophobic interdomain interface includes a metal-binding site, presumably involved in stabilizing the relative orientation between domains and predicted by sequence comparision to be present in the vertebrate homolog molecule L1. The neuroglian domains are related by a near perfect 2-fold screw axis along the longest molecular dimension. Using this relationship, a model for arrays of tandem fibronectin type III repeats in neuroglian and other molecules is proposed.

PubMed: 7512815
DOI: 10.1016/0896-6273(94)90326-3

実験手法

X-RAY DIFFRACTION (2 Å)