1CDM

MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES

1CDM の概要

• エントリーDOI: 10.2210/pdb1cdm/pdb
• 分子名称: PEPTIDE CALMODULIN-DEPENDENT PROTEIN KINASE II, CALMODULIN, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: calcium-binding protein
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Cytoplasm: P62157; Cell junction, synapse, presynaptic cell membrane: P11275
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 19324.71

構造登録者

Meador, W.E.,Quiocho, F.A. (登録日: 1993-10-08, 公開日: 1994-08-31, 最終更新日: 2024-02-07)

主引用文献

Meador, W.E.,Means, A.R.,Quiocho, F.A.
Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.
Science, 262:1718-1721, 1993

PubMed Abstract: Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.

PubMed: 8259515

実験手法

X-RAY DIFFRACTION (2 Å)