1CDI

STRUCTURES OF AN HIV AND MHC BINDING FRAGMENT FROM HUMAN CD4 AS REFINED IN TWO CRYSTAL LATTICES

1CDI の概要

• エントリーDOI: 10.2210/pdb1cdi/pdb
• 分子名称: T CELL SURFACE GLYCOPROTEIN CD4 (1 entity in total)
• 機能のキーワード: t-cell surface glycoprotein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19826.52

構造登録者

Ryu, S.E.,Truneh, A.,Sweet, R.W.,Hendrickson, W.A. (登録日: 1994-01-26, 公開日: 1994-04-30, 最終更新日: 2024-10-30)

主引用文献

Ryu, S.E.,Truneh, A.,Sweet, R.W.,Hendrickson, W.A.
Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices.
Structure, 2:59-74, 1994

PubMed Abstract: The T-cell surface glycoprotein CD4 interacts with class II molecules of the major histocompatibility complex (MHC) enhancing the signal for T-cell activation. Human CD4 also interacts, at high affinity, with the HIV envelope glycoprotein, gp120, to mediate T-cell infection by HIV. Crystal structures of amino-terminal two-domain (D1D2) fragments of human CD4, which contain the residues implicated in HIV and MHC interactions, have been reported earlier.

PubMed: 8075984
DOI: 10.1016/S0969-2126(00)00008-3

実験手法

X-RAY DIFFRACTION (2.9 Å)