1CD8

CRYSTAL STRUCTURE OF A SOLUBLE FORM OF THE HUMAN T CELL CO-RECEPTOR CD8 AT 2.6 ANGSTROMS RESOLUTION

1CD8 の概要

• エントリーDOI: 10.2210/pdb1cd8/pdb
• 分子名称: T CELL CORECEPTOR CD8, SULFATE ION (3 entities in total)
• 機能のキーワード: surface glycoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P01732
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12945.61

構造登録者

Leahy, D.J.,Axel, R.,Hendrickson, W.A. (登録日: 1992-01-16, 公開日: 1994-01-31, 最終更新日: 2024-10-30)

主引用文献

Leahy, D.J.,Axel, R.,Hendrickson, W.A.
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution.
Cell(Cambridge,Mass.), 68:1145-1162, 1992

PubMed Abstract: A secreted fragment of the extracellular portion of human CD8 alpha has been expressed in CHO cells, and a deglycosylated and proteolyzed form of this fragment has been crystallized. We report here the crystal structure of this fragment as refined at 2.6 A resolution. The structure was solved by molecular replacement using a superposition of ten variable domains from immunoglobulin light chains as the search model. Only the N-terminal 114 amino acids of CD8 alpha are visible in the electron density maps. The domain formed by these residues possesses a fold typical of immunoglobulin variable domains and associates to form Fv-like homodimers.

PubMed: 1547508
DOI: 10.1016/0092-8674(92)90085-Q

実験手法

X-RAY DIFFRACTION (2.6 Å)