1C8Z

C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN

1C8Z の概要

• エントリーDOI: 10.2210/pdb1c8z/pdb
• 分子名称: TUBBY PROTEIN, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: tubby filled-barrel, beta-barrel, filled-beta-roll, 12-stranded-beta-barrel, helix-filled-barrel, obesity blindness, deafness, signaling protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30186.15

構造登録者

Boggon, T.J.,Myers, S.C.,Shapiro, L. (登録日: 1999-07-30, 公開日: 1999-12-12, 最終更新日: 2024-02-07)

主引用文献

Boggon, T.J.,Shan, W.S.,Santagata, S.,Myers, S.C.,Shapiro, L.
Implication of tubby proteins as transcription factors by structure-based functional analysis.
Science, 286:2119-2125, 1999

PubMed Abstract: Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.

PubMed: 10591637
DOI: 10.1126/science.286.5447.2119

実験手法

X-RAY DIFFRACTION (1.9 Å)