1C4P

BETA DOMAIN OF STREPTOKINASE

1C4P の概要

• エントリーDOI: 10.2210/pdb1c4p/pdb
• 関連するPDBエントリー: 1BML
• 分子名称: PROTEIN (STREPTOKINASE) (2 entities in total)
• 機能のキーワード: plasminogen activator, blood clotting
• 由来する生物種: Streptococcus dysgalactiae subsp. equisimilis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63322.62

構造登録者

Wang, X.,Zhang, X.C. (登録日: 1999-09-15, 公開日: 1999-10-13, 最終更新日: 2023-12-27)

主引用文献

Wang, X.,Tang, J.,Hunter, B.,Zhang, X.C.
Crystal structure of streptokinase beta-domain.
FEBS Lett., 459:85-89, 1999

PubMed Abstract: Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.

PubMed: 10508922
DOI: 10.1016/S0014-5793(99)01214-4

実験手法

X-RAY DIFFRACTION (2.4 Å)