1C4D

GRAMICIDIN CSCL COMPLEX

Summary for 1C4D

• Entry DOI: 10.2210/pdb1c4d/pdb
• Related: 1AL4 1ALX 1ALZ 1AV2 1BDW 1GMK 1GRM 1JNO 1JO3 1JO4 1KQE 1MAG 1MIC 1NG8 1NRM 1NRU 1NT5 1NT6 1TK2 1TKQ 1W5U 2IZQ 2XDC 3L8L
• Related PRD ID: PRD_000150
• Descriptor: GRAMICIDIN A, CESIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: antibiotic, gramicidin, antifungal, antibacterial, double helix, membrane ion channel, linear gramicidin
• Biological source: BREVIBACILLUS BREVIS
• Total number of polymer chains: 4
• Total formula weight: 9221.68

Authors

Wallace, B.A. (deposition date: 1999-06-04, release date: 2000-01-03, Last modification date: 2024-10-16)

Primary citation

Wallace, B.A.,Ravikumar, K.
The Gramicidin Pore: Crystal Structure of a Cesium Complex.
Science, 241:182-, 1988

PubMed Abstract: Gramicidin, a linear polypeptide composed of hydrophobic amino acids with alternating L- and D- configurations, forms transmembrane ion channels. The crystal structure of a gramicidin-cesium complex has been determined at 2.0 angstrom resolution. In this structure, gramicidin forms a 26 angstrom long tube comprised of two polypeptide chains arranged as antiparallel beta strands that are wrapped into a left-handed helical coil with 6.4 residues per turn. The polypeptide backbone forms the interior of the hydrophilic, solvent-filled pore and the side chains form a hydrophobic and relatively regular surface on the outside of the pore. This example of a crystal structure of a solvent-filled ion pore provides a basis for understanding the physical nature of ion translocation.

PubMed: 2455344
DOI: 10.1126/SCIENCE.2455344

Experimental method

X-RAY DIFFRACTION (2 Å)