1C3E
NEW INSIGHTS INTO INHIBITOR DESIGN FROM THE CRYSTAL STRUCTURE AND NMR STUDIES OF E. COLI GAR TRANSFORMYLATE IN COMPLEX WITH BETA-GAR AND 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID.
Summary for 1C3E
Entry DOI | 10.2210/pdb1c3e/pdb |
Related | 1c2t |
Descriptor | GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, 2-{4-[2-(2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL)-1-CARBOXY-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, GLYCINAMIDE RIBONUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | purine biosynthesis, anti-cancer agent, inhibitor complex, transferase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 47435.15 |
Authors | Greasley, S.E.,Yamashita, M.M.,Cai, H.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A. (deposition date: 1999-07-27, release date: 1999-12-29, Last modification date: 2024-02-07) |
Primary citation | Greasley, S.E.,Yamashita, M.M.,Cai, H.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A. New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid. Biochemistry, 38:16783-16793, 1999 Cited by PubMed: 10606510DOI: 10.1021/bi991888a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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