1C3E

NEW INSIGHTS INTO INHIBITOR DESIGN FROM THE CRYSTAL STRUCTURE AND NMR STUDIES OF E. COLI GAR TRANSFORMYLATE IN COMPLEX WITH BETA-GAR AND 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID.

1C3E の概要

• エントリーDOI: 10.2210/pdb1c3e/pdb
• 関連するPDBエントリー: 1c2t
• 分子名称: GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, 2-{4-[2-(2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL)-1-CARBOXY-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, GLYCINAMIDE RIBONUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: purine biosynthesis, anti-cancer agent, inhibitor complex, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47435.15

構造登録者

Greasley, S.E.,Yamashita, M.M.,Cai, H.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A. (登録日: 1999-07-27, 公開日: 1999-12-29, 最終更新日: 2024-02-07)

• 主引用文献: Greasley, S.E.,Yamashita, M.M.,Cai, H.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A.; New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.; Biochemistry, 38:16783-16793, 1999; PubMed: 10606510; DOI: 10.1021/bi991888a

実験手法

X-RAY DIFFRACTION (2.1 Å)