1C3C

T. MARITIMA ADENYLOSUCCINATE LYASE

1C3C の概要

• エントリーDOI: 10.2210/pdb1c3c/pdb
• 分子名称: PROTEIN (ADENYLOSUCCINATE LYASE) (2 entities in total)
• 機能のキーワード: purine biosynthesis, lyase
• 由来する生物種: Thermotoga maritima
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 99375.66

構造登録者

Toth, E.A.,Yeates, T.O. (登録日: 1999-07-27, 公開日: 2000-02-09, 最終更新日: 2024-02-07)

主引用文献

Toth, E.A.,Yeates, T.O.
The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway.
Structure Fold.Des., 8:163-174, 2000

PubMed Abstract: Adenylosuccinate lyase is an enzyme that plays a critical role in both cellular replication and metabolism via its action in the de novo purine biosynthetic pathway. Adenylosuccinate lyase is the only enzyme in this pathway to catalyze two separate reactions, enabling it to participate in the addition of a nitrogen at two different positions in adenosine monophosphate. Both reactions catalyzed by adenylosuccinate lyase involve the beta-elimination of fumarate. Enzymes that catalyze this type of reaction belong to a superfamily, the members of which are homotetramers. Because adenylosuccinate lyase plays an integral part in maintaining proper cellular metabolism, mutations in the human enzyme can have severe clinical consequences, including mental retardation with autistic features.

PubMed: 10673438
DOI: 10.1016/S0969-2126(00)00092-7

実験手法

X-RAY DIFFRACTION (1.8 Å)