1C1E
CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN
Summary for 1C1E
| Entry DOI | 10.2210/pdb1c1e/pdb |
| Descriptor | CATALYTIC ANTIBODY 1E9 (LIGHT CHAIN), CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN), D-MALATE, ... (5 entities in total) |
| Functional Keywords | catalytic antibody, diels-alder, immunoglobulin, immune system |
| Biological source | Mus musculus (house mouse) More |
| Total number of polymer chains | 2 |
| Total formula weight | 48008.32 |
| Authors | Xu, J.,Wilson, I.A. (deposition date: 1999-07-22, release date: 2000-03-01, Last modification date: 2024-10-16) |
| Primary citation | Xu, J.,Deng, Q.,Chen, J.,Houk, K.N.,Bartek, J.,Hilvert, D.,Wilson, I.A. Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. Science, 286:2345-2348, 1999 Cited by PubMed Abstract: The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency. PubMed: 10600746DOI: 10.1126/science.286.5448.2345 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report
