1C1E

CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN

1C1E の概要

• エントリーDOI: 10.2210/pdb1c1e/pdb
• 分子名称: CATALYTIC ANTIBODY 1E9 (LIGHT CHAIN), CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN), D-MALATE, ... (5 entities in total)
• 機能のキーワード: catalytic antibody, diels-alder, immunoglobulin, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48008.32

構造登録者

Xu, J.,Wilson, I.A. (登録日: 1999-07-22, 公開日: 2000-03-01, 最終更新日: 2024-10-16)

主引用文献

Xu, J.,Deng, Q.,Chen, J.,Houk, K.N.,Bartek, J.,Hilvert, D.,Wilson, I.A.
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.
Science, 286:2345-2348, 1999

PubMed Abstract: The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.

PubMed: 10600746
DOI: 10.1126/science.286.5448.2345

実験手法

X-RAY DIFFRACTION (1.9 Å)