1BZR

ATOMIC RESOLUTION CRYSTAL STRUCTURE ANALYSIS OF NATIVE DEOXY AND CO MYOGLOBIN FROM SPERM WHALE AT ROOM TEMPERATURE

1BZR の概要

• エントリーDOI: 10.2210/pdb1bzr/pdb
• 分子名称: PROTEIN (MYOGLOBIN), SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: carbonmonoxy myoglobin, atomic resolution, oxygen storage
• 由来する生物種: Physeter catodon (sperm whale)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18071.57

構造登録者

Kachalova, G.S.,Popov, A.N.,Bartunik, H.D. (登録日: 1998-11-03, 公開日: 1999-05-10, 最終更新日: 2023-08-09)

主引用文献

Kachalova, G.S.,Popov, A.N.,Bartunik, H.D.
A steric mechanism for inhibition of CO binding to heme proteins.
Science, 284:473-476, 1999

PubMed Abstract: The crystal structures of myoglobin in the deoxy- and carbon monoxide-ligated states at a resolution of 1.15 angstroms show that carbon monoxide binding at ambient temperatures requires concerted motions of the heme, the iron, and helices E and F for relief of steric inhibition. These steps constitute the main mechanism by which heme proteins lower the affinity of the heme group for the toxic ligand carbon monoxide.

PubMed: 10205052
DOI: 10.1126/science.284.5413.473

実験手法

X-RAY DIFFRACTION (1.15 Å)