1BZJ

Human ptp1b complexed with tpicooh

1BZJ の概要

• エントリーDOI: 10.2210/pdb1bzj/pdb
• 分子名称: PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE), 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID (3 entities in total)
• 機能のキーワード: phosphorylation, inhibitor complex, protein tyrosine phosphatase, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34891.54

構造登録者

Groves, M.R.,Yao, Z.-J.,Barford Jr., D.T.B. (登録日: 1998-10-29, 公開日: 1999-02-16, 最終更新日: 2023-08-09)

• 主引用文献: Groves, M.R.,Yao, Z.-J.,Roller, P.P.,Burke Jr., T.R.,Barford, D.; Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.; Biochemistry, 37:17773-17783, 1998; PubMed: 9922143; DOI: 10.1021/bi9816958

実験手法

X-RAY DIFFRACTION (2.25 Å)