1BXO

ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL CYCLO[(2S)-2-[[(1R)-1-(N-(L-N-(3-METHYLBUTANOYL)VALYL-L-ASPARTYL)AMINO)-3-METHYLBUT YL] HYDROXYPHOSPHINYLOXY]-3-(3-AMINOMETHYL) PHENYLPROPANOATE

Summary for 1BXO

• Entry DOI: 10.2210/pdb1bxo/pdb
• Descriptor: PROTEIN (PENICILLOPEPSIN), alpha-D-mannopyranose, SULFATE ION, ... (6 entities in total)
• Functional Keywords: hydrolase, phosphonate inhibitors, macrocycle
• Biological source: Penicillium janthinellum
• Total number of polymer chains: 1
• Total formula weight: 34748.06

Authors

Khan, A.R.,Parrish, J.C.,Fraser, M.E.,Smith, W.W.,Bartlett, P.A.,James, M.N.G. (deposition date: 1998-10-07, release date: 1998-10-14, Last modification date: 2023-08-09)

• Primary citation: Khan, A.R.,Parrish, J.C.,Fraser, M.E.,Smith, W.W.,Bartlett, P.A.,James, M.N.; Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes.; Biochemistry, 37:16839-16845, 1998; PubMed: 9836576; DOI: 10.1021/bi9821364

Experimental method

X-RAY DIFFRACTION (0.95 Å)