1BXO

ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL CYCLO[(2S)-2-[[(1R)-1-(N-(L-N-(3-METHYLBUTANOYL)VALYL-L-ASPARTYL)AMINO)-3-METHYLBUT YL] HYDROXYPHOSPHINYLOXY]-3-(3-AMINOMETHYL) PHENYLPROPANOATE

1BXO の概要

• エントリーDOI: 10.2210/pdb1bxo/pdb
• 分子名称: PROTEIN (PENICILLOPEPSIN), alpha-D-mannopyranose, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: hydrolase, phosphonate inhibitors, macrocycle
• 由来する生物種: Penicillium janthinellum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34748.06

構造登録者

Khan, A.R.,Parrish, J.C.,Fraser, M.E.,Smith, W.W.,Bartlett, P.A.,James, M.N.G. (登録日: 1998-10-07, 公開日: 1998-10-14, 最終更新日: 2023-08-09)

• 主引用文献: Khan, A.R.,Parrish, J.C.,Fraser, M.E.,Smith, W.W.,Bartlett, P.A.,James, M.N.; Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes.; Biochemistry, 37:16839-16845, 1998; PubMed: 9836576; DOI: 10.1021/bi9821364

実験手法

X-RAY DIFFRACTION (0.95 Å)