1BXE

RIBOSOMAL PROTEIN L22 FROM THERMUS THERMOPHILUS

1BXE の概要

• エントリーDOI: 10.2210/pdb1bxe/pdb
• 分子名称: PROTEIN (RIBOSOMAL PROTEIN L22), CHLORIDE ION (3 entities in total)
• 機能のキーワード: ribosomal protein, protein synthesis, rna binding, antibiotics resistance, rna binding protein
• 由来する生物種: Thermus thermophilus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13008.20

構造登録者

Unge, J.,Aberg, A.,Al-Karadaghi, S.,Nikulin, A.,Nikonov, S.,Davydova, N.,Nevskaya, N.,Garber, M.,Liljas, A. (登録日: 1998-10-02, 公開日: 1998-10-07, 最終更新日: 2024-10-30)

主引用文献

Unge, J.,berg, A.,Al-Kharadaghi, S.,Nikulin, A.,Nikonov, S.,Davydova, N.,Nevskaya, N.,Garber, M.,Liljas, A.
The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance.
Structure, 6:1577-1586, 1998

PubMed Abstract: . The ribosomal protein L22 is one of five proteins necessary for the formation of an early folding intermediate of the 23S rRNA. L22 has been found on the cytoplasmic side of the 50S ribosomal subunit. It can also be labeled by an erythromycin derivative bound close to the peptidyl-transfer center at the interface side of the 50S subunit, and the amino acid sequence of an erythromycin-resistant mutant is known. Knowing the structure of the protein may resolve this apparent conflict regarding the location of L22 on the ribosome.

PubMed: 9862810
DOI: 10.1016/S0969-2126(98)00155-5

実験手法

X-RAY DIFFRACTION (1.9 Å)