1BX7

HIRUSTASIN FROM HIRUDO MEDICINALIS AT 1.2 ANGSTROMS

1BX7 の概要

• エントリーDOI: 10.2210/pdb1bx7/pdb
• 分子名称: HIRUSTASIN, SULFATE ION (3 entities in total)
• 機能のキーワード: anti-coagulant, peptidic inhibitors, conformational flexibility, serine protease inhibitor
• 由来する生物種: Hirudo medicinalis (medicinal leech)
• 細胞内の位置: Secreted: P80302
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6078.91

構造登録者

Uson, I.,Sheldrick, G.M.,De La Fortelle, E.,Bricogne, G.,Di Marco, S.,Priestle, J.P.,Gruetter, M.G.,Mittl, P.R.E. (登録日: 1998-10-14, 公開日: 1999-04-27, 最終更新日: 2024-10-23)

主引用文献

Uson, I.,Sheldrick, G.M.,de La Fortelle, E.,Bricogne, G.,Di Marco, S.,Priestle, J.P.,Grutter, M.G.,Mittl, P.R.
The 1.2 A crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors.
Structure Fold.Des., 7:55-63, 1999

PubMed Abstract: Leech-derived inhibitors have a prominent role in the development of new antithrombotic drugs, because some of them are able to block the blood coagulation cascade. Hirustasin, a serine protease inhibitor from the leech Hirudo medicinalis, binds specifically to tissue kallikrein and possesses structural similarity with antistasin, a potent factor Xa inhibitor from Haementeria officinalis. Although the 2.4 A structure of the hirustasin-kallikrein complex is known, classical methods such as molecular replacement were not successful in solving the structure of free hirustasin.

PubMed: 10368273
DOI: 10.1016/S0969-2126(99)80009-4

実験手法

X-RAY DIFFRACTION (1.2 Å)