1BWG

DNA TRIPLEX WITH 5' AND 3' JUNCTIONS, NMR, 10 STRUCTURES

1BWG の概要

• エントリーDOI: 10.2210/pdb1bwg/pdb
• 関連するPDBエントリー: 1BCB 1BCE
• 分子名称: DNA (5'-D(*GP*AP*CP*TP*GP*AP*GP*AP*GP*AP*CP*GP*TP*A)-3'), DNA (5'-D(*TP*AP*CP*GP*TP*CP*TP*CP*TP*CP*AP*GP*TP*C)-3'), DNA (5'-D(*CP*TP*CP*TP*CP*T)-3') (3 entities in total)
• 機能のキーワード: deoxyribonucleic acid, dna triplex, triplex-duplex junctions, dna
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 10295.76

構造登録者

Asensio, J.L.,Brown, T.,Lane, A.N. (登録日: 1998-09-22, 公開日: 1999-03-23, 最終更新日: 2024-05-22)

主引用文献

Asensio, J.L.,Brown, T.,Lane, A.N.
Solution conformation of a parallel DNA triple helix with 5' and 3' triplex-duplex junctions.
Structure Fold.Des., 7:1-11, 1999

PubMed Abstract: Polypurine x polypyrimidine sequences of DNA can form parallel triple helices via Hoogsteen hydrogen bonds with a third DNA strand that is complementary to the purine strand. The triplex prevents transcription and could therefore potentially be used to regulate specific genes. The determination of the structures of triplex-duplex junctions can help us to understand the structural basis of specificity, and aid in the design of optimal antigene oligonucleotides.

PubMed: 10368268
DOI: 10.1016/S0969-2126(99)80004-5

実験手法

SOLUTION NMR