1BVJ

HIV-1 RNA A-RICH HAIRPIN LOOP

Summary for 1BVJ

• Entry DOI: 10.2210/pdb1bvj/pdb
• Descriptor: RNA (5'-R(P*GP*GP*CP*GP*AP*CP*GP*GP*UP*GP*UP*AP*AP*AP*AP*AP*UP*CP*UP*CP*GP*CP* C)-3') (1 entity in total)
• Functional Keywords: hiv-1 genomic rna, reverse transcriptase initiation, rna hairpin loop, rna
• Biological source: Human immunodeficiency virus type 1 (MAL ISOLATE)
• Total number of polymer chains: 1
• Total formula weight: 7402.47

Authors

Puglisi, E.V.,Puglisi, J.D. (deposition date: 1998-08-31, release date: 1998-12-09, Last modification date: 2024-05-22)

Primary citation

Puglisi, E.V.,Puglisi, J.D.
HIV-1 A-rich RNA loop mimics the tRNA anticodon structure.
Nat.Struct.Biol., 5:1033-1036, 1998

PubMed Abstract: Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.

PubMed: 9846871
DOI: 10.1038/4141

Experimental method

SOLUTION NMR