1BVJ

HIV-1 RNA A-RICH HAIRPIN LOOP

1BVJ の概要

• エントリーDOI: 10.2210/pdb1bvj/pdb
• 分子名称: RNA (5'-R(P*GP*GP*CP*GP*AP*CP*GP*GP*UP*GP*UP*AP*AP*AP*AP*AP*UP*CP*UP*CP*GP*CP* C)-3') (1 entity in total)
• 機能のキーワード: hiv-1 genomic rna, reverse transcriptase initiation, rna hairpin loop, rna
• 由来する生物種: Human immunodeficiency virus type 1 (MAL ISOLATE)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7402.47

構造登録者

Puglisi, E.V.,Puglisi, J.D. (登録日: 1998-08-31, 公開日: 1998-12-09, 最終更新日: 2024-05-22)

主引用文献

Puglisi, E.V.,Puglisi, J.D.
HIV-1 A-rich RNA loop mimics the tRNA anticodon structure.
Nat.Struct.Biol., 5:1033-1036, 1998

PubMed Abstract: Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.

PubMed: 9846871
DOI: 10.1038/4141

実験手法

SOLUTION NMR