1BVE

HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES

1BVE の概要

• エントリーDOI: 10.2210/pdb1bve/pdb
• 関連するPDBエントリー: 1BVG
• 分子名称: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE (2 entities in total)
• 機能のキーワード: aids, polyprotein, hydrolase, aspartyl protease, endonuclease, rna-directed dna polymerase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22082.02

構造登録者

Yamazaki, T.,Hinck, A.P.,Wang, Y.-X.,Nicholson, L.K.,Torchia, D.A.,Wingfield, P.,Stahl, S.J.,Kaufman, J.D.,Chang, C.,Domaille, P.J.,Lam, P.Y.S. (登録日: 1996-01-16, 公開日: 1996-08-17, 最終更新日: 2021-11-03)

• 主引用文献: Yamazaki, T.,Hinck, A.P.,Wang, Y.X.,Nicholson, L.K.,Torchia, D.A.,Wingfield, P.,Stahl, S.J.,Kaufman, J.D.,Chang, C.H.,Domaille, P.J.,Lam, P.Y.; Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy.; Protein Sci., 5:495-506, 1996; PubMed: 8868486

実験手法

SOLUTION NMR