1BUN

STRUCTURE OF BETA2-BUNGAROTOXIN: POTASSIUM CHANNEL BINDING BY KUNITZ MODULES AND TARGETED PHOSPHOLIPASE ACTION

1BUN の概要

• エントリーDOI: 10.2210/pdb1bun/pdb
• 分子名称: BETA2-BUNGAROTOXIN, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, presynaptic neurotoxin, toxin
• 由来する生物種: Bungarus multicinctus (many-banded krait); 詳細
• 細胞内の位置: Secreted: P00617 P00989
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20780.66

構造登録者

Kwong, P.D.,Mcdonald, N.Q.,Sigler, P.B.,Hendrickson, W.A. (登録日: 1995-10-15, 公開日: 1996-04-03, 最終更新日: 2024-10-30)

主引用文献

Kwong, P.D.,McDonald, N.Q.,Sigler, P.B.,Hendrickson, W.A.
Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action.
Structure, 3:1109-1119, 1995

PubMed Abstract: beta-bungarotoxin is a heterodimeric neurotoxin consisting of a phospholipase subunit linked by a disulfide bond to a K+ channel binding subunit which is a member of the Kunitz protease inhibitor superfamily. Toxicity, characterized by blockage of neural transmission, is achieved by the lipolytic action of the phospholipase targeted to the presynaptic membrane by the Kunitz module.

PubMed: 8590005
DOI: 10.1016/S0969-2126(01)00246-5

実験手法

X-RAY DIFFRACTION (2.45 Å)