Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1BQ6

CHALCONE SYNTHASE FROM ALFALFA WITH COENZYME A

1BQ6 の概要
エントリーDOI10.2210/pdb1bq6/pdb
分子名称CHALCONE SYNTHASE, SULFATE ION, COENZYME A, ... (4 entities in total)
機能のキーワードtransferase, polyketide synthase, chalcone biosynthesis
由来する生物種Medicago sativa
タンパク質・核酸の鎖数1
化学式量合計43519.68
構造登録者
Ferrer, J.-L.,Bowman, M.E.,Jez, J.,Dixon, R.,Noel, J.P. (登録日: 1998-08-21, 公開日: 1999-08-11, 最終更新日: 2024-10-16)
主引用文献Ferrer, J.L.,Jez, J.M.,Bowman, M.E.,Dixon, R.A.,Noel, J.P.
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.
Nat.Struct.Biol., 6:775-784, 1999
Cited by
PubMed Abstract: Chalcone synthase (CHS) is pivotal for the biosynthesis of flavonoid antimicrobial phytoalexins and anthocyanin pigments in plants. It produces chalcone by condensing one p-coumaroyl- and three malonyl-coenzyme A thioesters into a polyketide reaction intermediate that cyclizes. The crystal structures of CHS alone and complexed with substrate and product analogs reveal the active site architecture that defines the sequence and chemistry of multiple decarboxylation and condensation reactions and provides a molecular understanding of the cyclization reaction leading to chalcone synthesis. The structure of CHS complexed with resveratrol also suggests how stilbene synthase, a related enzyme, uses the same substrates and an alternate cyclization pathway to form resveratrol. By using the three-dimensional structure and the large database of CHS-like sequences, we can identify proteins likely to possess novel substrate and product specificity. The structure elucidates the chemical basis of plant polyketide biosynthesis and provides a framework for engineering CHS-like enzymes to produce new products.
PubMed: 10426957
DOI: 10.1038/11553
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.56 Å)
構造検証レポート
Validation report summary of 1bq6
検証レポート(詳細版)ダウンロードをダウンロード

227111

件を2024-11-06に公開中

PDB statisticsPDBj update infoContact PDBjnumon