1BOZ

STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS

Summary for 1BOZ

Entry DOI	10.2210/pdb1boz/pdb
Descriptor	PROTEIN (DIHYDROFOLATE REDUCTASE), NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE, ... (4 entities in total)
Functional Keywords	oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P00374
Total number of polymer chains	1
Total formula weight	22345.20
Authors	Gangjee, A.,Vidwans, A.P.,Vasudevan, A.,Queener, S.F.,Kisliuk, R.L.,Cody, V.,Li, R.,Galitsky, N.,Luft, J.R.,Pangborn, W. (deposition date: 1998-08-06, release date: 1998-08-12, Last modification date: 2022-12-21)
Primary citation	Gangjee, A.,Vidwans, A.P.,Vasudevan, A.,Queener, S.F.,Kisliuk, R.L.,Cody, V.,Li, R.,Galitsky, N.,Luft, J.R.,Pangborn, W. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. J.Med.Chem., 41:3426-3434, 1998 Cited by PubMed: 9719595 DOI: 10.1021/jm980081y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation