1BOZ
STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS
Summary for 1BOZ
Entry DOI | 10.2210/pdb1boz/pdb |
Descriptor | PROTEIN (DIHYDROFOLATE REDUCTASE), NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE, ... (4 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion : P00374 |
Total number of polymer chains | 1 |
Total formula weight | 22345.20 |
Authors | Gangjee, A.,Vidwans, A.P.,Vasudevan, A.,Queener, S.F.,Kisliuk, R.L.,Cody, V.,Li, R.,Galitsky, N.,Luft, J.R.,Pangborn, W. (deposition date: 1998-08-06, release date: 1998-08-12, Last modification date: 2024-05-22) |
Primary citation | Gangjee, A.,Vidwans, A.P.,Vasudevan, A.,Queener, S.F.,Kisliuk, R.L.,Cody, V.,Li, R.,Galitsky, N.,Luft, J.R.,Pangborn, W. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. J.Med.Chem., 41:3426-3434, 1998 Cited by PubMed: 9719595DOI: 10.1021/jm980081y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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