1BMP

BONE MORPHOGENETIC PROTEIN-7

Summary for 1BMP

• Entry DOI: 10.2210/pdb1bmp/pdb
• Descriptor: BONE MORPHOGENETIC PROTEIN-7 (1 entity in total)
• Functional Keywords: morphogen, transforming growth factor, cytokine, bone, cartilage, glycoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15699.73

Authors

Griffith, D.L.,Scott, D.L. (deposition date: 1995-12-14, release date: 1997-07-23, Last modification date: 2024-06-05)

Primary citation

Griffith, D.L.,Keck, P.C.,Sampath, T.K.,Rueger, D.C.,Carlson, W.D.
Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
Proc.Natl.Acad.Sci.USA, 93:878-883, 1996

PubMed Abstract: We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.

PubMed: 8570652
DOI: 10.1073/pnas.93.2.878

Experimental method

X-RAY DIFFRACTION (2.8 Å)