1BMM

HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R*,R*)]-4-[(AMINOIMINOMETHYL)AMINO]-N-[[1-[3-HYDROXY-2-[(2-NAPHTHALENYLSULFONYL)AMINO]-1-OXOPROPYL]-2-PYRROLIDINYL] METHYL]BUTANAMIDE (BMS-186282)

1BMM の概要

• エントリーDOI: 10.2210/pdb1bmm/pdb
• 分子名称: ALPHA-THROMBIN, HIRUDIN I, S-(R*,R*)]-4-[AMINOIMINOMETHYL)AMINO]-N-[[1-[3-HYDROXY -2-[(2-NAPHTHALENYLSULFONYL)AMINO]-1-OXOPROPYL]-2-PYRROLIDINYL] METHYL]BUTANAMIDE, ... (5 entities in total)
• 機能のキーワード: serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28507
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35849.87

構造登録者

Malley, M.,Sack, J. (登録日: 1995-11-14, 公開日: 1996-12-07, 最終更新日: 2011-07-13)

• 主引用文献: Malley, M.F.,Tabernero, L.,Chang, C.Y.,Ohringer, S.L.,Roberts, D.G.,Das, J.,Sack, J.S.; Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.; Protein Sci., 5:221-228, 1996; PubMed: 8745399

実験手法

X-RAY DIFFRACTION (2.6 Å)