1BML

COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE

1BML の概要

• エントリーDOI: 10.2210/pdb1bml/pdb
• 分子名称: PLASMIN, STREPTOKINASE (2 entities in total)
• 機能のキーワード: human plasmin, streptokinase, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted : P00747
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 136956.70

構造登録者

Wang, X.,Zhang, X.C. (登録日: 1999-05-25, 公開日: 1999-08-02, 最終更新日: 2024-10-16)

主引用文献

Wang, X.,Lin, X.,Loy, J.A.,Tang, J.,Zhang, X.C.
Crystal structure of the catalytic domain of human plasmin complexed with streptokinase.
Science, 281:1662-1665, 1998

PubMed Abstract: Streptokinase is a plasminogen activator widely used in treating blood-clotting disorders. Complexes of streptokinase with human plasminogen can hydrolytically activate other plasminogen molecules to plasmin, which then dissolves blood clots. A similar binding activation mechanism also occurs in some key steps of blood coagulation. The crystal structure of streptokinase complexed with the catalytic unit of human plasmin was solved at 2.9 angstroms. The amino-terminal domain of streptokinase in the complex is hypothesized to enhance the substrate recognition. The carboxyl-terminal domain of streptokinase, which binds near the activation loop of plasminogen, is likely responsible for the contact activation of plasminogen in the complex.

PubMed: 9733510
DOI: 10.1126/science.281.5383.1662

実験手法

X-RAY DIFFRACTION (2.9 Å)