1BKB

INITIATION FACTOR 5A FROM ARCHEBACTERIUM PYROBACULUM AEROPHILUM

Summary for 1BKB

Entry DOI	10.2210/pdb1bkb/pdb
Descriptor	TRANSLATION INITIATION FACTOR 5A (2 entities in total)
Functional Keywords	translation initiation factor, translation
Biological source	Pyrobaculum aerophilum
Total number of polymer chains	1
Total formula weight	15334.19
Authors	Peat, T.S.,Newman, J.,Waldo, G.S.,Berendzen, J.,Terwilliger, T.C. (deposition date: 1998-07-05, release date: 1998-11-04, Last modification date: 2024-10-30)
Primary citation	Peat, T.S.,Newman, J.,Waldo, G.S.,Berendzen, J.,Terwilliger, T.C. Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 A resolution. Structure, 6:1207-1214, 1998 Cited by PubMed Abstract: Translation initiation factor 5A (IF-5A) is reported to be involved in the first step of peptide bond formation in translation, to be involved in cell-cycle regulation and to be a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukemia virus I, respectively. IF-5A contains an unusual amino acid, hypusine (N-epsilon-(4-aminobutyl-2-hydroxy)lysine), that is required for its function. The first step in the post-translational modification of lysine to hypusine is catalyzed by the enzyme deoxyhypusine synthase, the structure of which has been published recently. PubMed: 9753699 DOI: 10.1016/S0969-2126(98)00120-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation