1BKB

INITIATION FACTOR 5A FROM ARCHEBACTERIUM PYROBACULUM AEROPHILUM

1BKB の概要

• エントリーDOI: 10.2210/pdb1bkb/pdb
• 分子名称: TRANSLATION INITIATION FACTOR 5A (2 entities in total)
• 機能のキーワード: translation initiation factor, translation
• 由来する生物種: Pyrobaculum aerophilum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15334.19

構造登録者

Peat, T.S.,Newman, J.,Waldo, G.S.,Berendzen, J.,Terwilliger, T.C. (登録日: 1998-07-05, 公開日: 1998-11-04, 最終更新日: 2024-10-30)

主引用文献

Peat, T.S.,Newman, J.,Waldo, G.S.,Berendzen, J.,Terwilliger, T.C.
Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 A resolution.
Structure, 6:1207-1214, 1998

PubMed Abstract: Translation initiation factor 5A (IF-5A) is reported to be involved in the first step of peptide bond formation in translation, to be involved in cell-cycle regulation and to be a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukemia virus I, respectively. IF-5A contains an unusual amino acid, hypusine (N-epsilon-(4-aminobutyl-2-hydroxy)lysine), that is required for its function. The first step in the post-translational modification of lysine to hypusine is catalyzed by the enzyme deoxyhypusine synthase, the structure of which has been published recently.

PubMed: 9753699
DOI: 10.1016/S0969-2126(98)00120-8

実験手法

X-RAY DIFFRACTION (1.75 Å)