1BJ8

THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE

1BJ8 の概要

• エントリーDOI: 10.2210/pdb1bj8/pdb
• 分子名称: GP130 (1 entity in total)
• 機能のキーワード: receptor, signal transducer of il-6 type cytokines, third n-terminal domain, transmembrane, glycoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12652.17

構造登録者

Kernebeck, T.,Pflanz, S.,Muller-Newen, G.,Kurapkat, G.,Scheek, R.M.,Dijkstra, K.,Heinrich, P.C.,Wollmer, A.,Grzesiek, S.,Grotzinger, J. (登録日: 1998-07-02, 公開日: 1999-01-13, 最終更新日: 2024-05-22)

主引用文献

Kernebeck, T.,Pflanz, S.,Muller-Newen, G.,Kurapkat, G.,Scheek, R.M.,Dijkstra, K.,Heinrich, P.C.,Wollmer, A.,Grzesiek, S.,Grotzinger, J.
The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region.
Protein Sci., 8:5-12, 1999

PubMed Abstract: The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.

PubMed: 10210178

実験手法

SOLUTION NMR