1BJ7

BOVINE LIPOCALIN ALLERGEN BOS D 2

1BJ7 の概要

• エントリーDOI: 10.2210/pdb1bj7/pdb
• 分子名称: D 2 (2 entities in total)
• 機能のキーワード: allergen, lipocalin
• 由来する生物種: Bos taurus (cattle)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17867.98

構造登録者

Rouvinen, J. (登録日: 1998-07-02, 公開日: 1999-05-11, 最終更新日: 2024-10-23)

主引用文献

Rouvinen, J.,Rautiainen, J.,Virtanen, T.,Zeiler, T.,Kauppinen, J.,Taivainen, A.,Mantyjarvi, R.
Probing the molecular basis of allergy. three-dimensional structure of the bovine lipocalin allergen Bos d 2.
J.Biol.Chem., 274:2337-2343, 1999

PubMed Abstract: The three-dimensional structure of the major bovine allergen Bos d 2 has been determined by using x-ray diffraction at 1.8-A resolution. Structurally Bos d 2 is a member of the lipocalin family comprising proteins with transport functions. There is a flat small cavity inside the Bos d 2 protein core suitable for ligand binding, and it is possible that Glu115 and Asn37 inside the core are able to make hydrogen bonds with the ligand. Many allergens from different animals belong to the lipocalin family. The amino acid residue similarities between these lipocalins indicate putative regions for IgE binding. Comparison with the available allergen structures from other sources suggests that these allergens are roughly the same size and that their shape is more spherical than elliptical.

PubMed: 9891000
DOI: 10.1074/jbc.274.4.2337

実験手法

X-RAY DIFFRACTION (1.8 Å)