1BJ5

HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID

1BJ5 の概要

• エントリーDOI: 10.2210/pdb1bj5/pdb
• 分子名称: HUMAN SERUM ALBUMIN, MYRISTIC ACID (2 entities in total)
• 機能のキーワード: plasma protein, metal-binding, lipid-binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02768
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 67713.07

構造登録者

Curry, S.,Mandelkow, H.,Brick, P.,Franks, N. (登録日: 1998-07-02, 公開日: 1998-11-04, 最終更新日: 2011-07-13)

主引用文献

Curry, S.,Mandelkow, H.,Brick, P.,Franks, N.
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites.
Nat.Struct.Biol., 5:827-835, 1998

PubMed Abstract: Human serum albumin (HSA) is the most abundant protein in the circulatory system. Its principal function is to transport fatty acids, but it is also capable of binding a great variety of metabolites and drugs. Despite intensive efforts, the detailed structural basis of fatty acid binding to HSA has remained elusive. We have now determined the crystal structure of HSA complexed with five molecules of myristate at 2.5 A resolution. The fatty acid molecules bind in long, hydrophobic pockets capped by polar side chains, many of which are basic. These pockets are distributed asymmetrically throughout the HSA molecule, despite its symmetrical repeating domain structure.

PubMed: 9731778
DOI: 10.1038/1869

実験手法

X-RAY DIFFRACTION (2.5 Å)