1BHO

MAC-1 I DOMAIN MAGNESIUM COMPLEX

1BHO の概要

• エントリーDOI: 10.2210/pdb1bho/pdb
• 分子名称: CD11B, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: cell adhesion, integrin, i domain
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P11215
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43428.28

構造登録者

Baldwin, E.T. (登録日: 1998-06-10, 公開日: 1998-11-04, 最終更新日: 2024-10-30)

主引用文献

Baldwin, E.T.,Sarver, R.W.,Bryant Jr., G.L.,Curry, K.A.,Fairbanks, M.B.,Finzel, B.C.,Garlick, R.L.,Heinrikson, R.L.,Horton, N.C.,Kelley, L.L.,Mildner, A.M.,Moon, J.B.,Mott, J.E.,Mutchler, V.T.,Tomich, C.S.,Watenpaugh, K.D.,Wiley, V.H.
Cation binding to the integrin CD11b I domain and activation model assessment
Structure, 6:923-935, 1998

PubMed Abstract: The integrin family of cell-surface receptors mediate cell adhesion through interactions with the extracellular matrix or other cell-surface receptors. The alpha chain of some integrin heterodimers includes an inserted 'I domain' of about 200 amino acids which binds divalent metal ions and is essential for integrin function. Lee et al. proposed that the I domain of the integrin CD11b adopts a unique 'active' conformation when bound to its counter receptor. In addition, they proposed that the lack of adhesion in the presence of Ca2+ ion reflected the stabilization of an 'inactive' I-domain conformation. We set out to independently determine the structure of the CD11 b I domain and to evaluate the structural effects of divalent ion binding to this protein.

PubMed: 9687375
DOI: 10.1016/S0969-2126(98)00093-8

実験手法

X-RAY DIFFRACTION (2.7 Å)