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1BGO

CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR

Summary for 1BGO
Entry DOI10.2210/pdb1bgo/pdb
DescriptorCATHEPSIN K, 1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE (3 entities in total)
Functional Keywordshydrolase, sulfhydryl proteinase, thiol protease
Biological sourceHomo sapiens (human)
Cellular locationLysosome: P43235
Total number of polymer chains1
Total formula weight24005.09
Authors
Primary citationDesjarlais, R.L.,Yamashita, D.S.,Oh, H.J.,Uzinskas, I.N.,Erhard, K.F.,Allen, A.C.,Haltiwanger, R.C.,Zhao, B.G.,Smith, W.W.,Abdel-Meguid, S.S.,Dalessio, K.,Janson, C.A.,Mcqueney, M.S.,Tomaszek, T.A.,Levy, M.A.,Veber, D.F.
Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K
J.Am.Chem.Soc., 120:9114-, 1998
Cited by
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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